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No accepted diagnostic criteria of ADEM.
Previously healthy child
With sudden onset.
Polysymptomatic onset of neurological deficit not correlated with anatomic location
Presumptive post infectious or vaccination process
With encephalopathy i.e
Behavioral change
Alteration of consciousness
No etiology can explain the events
Younger age.

MRI Finding

Some enlighted features of ADEM that are unsual in MS.
Absolute of Relative periventricular sparing
Lack of sharply defined borders of the lesion